
Every vaccine the United States has ever rolled out has arrived with a shadow twin: a countermovement insisting the shot poses more danger than the disease it prevents, or that no government has the right to demand it. That pattern predates the country itself, and it has recurred with almost eerie consistency across three centuries — from the smallpox pustules of colonial Boston to the mRNA vials of 2021.
Colonial Boston and Smallpox
The story usually begins in Boston in 1721, during the sixth smallpox epidemic to strike the city since its founding. A ship called the Seahorse arrived from the Caribbean that April carrying a sailor with active smallpox, and within weeks the disease was moving through a city of roughly 11,000 people. By the time the epidemic burned out the following year, more than 6,000 Bostonians had been infected and about 850 had died.
The remedy that split the town in two was not vaccination in the modern sense but variolation, or inoculation — deliberately introducing live smallpox matter into a small cut in the skin, on the theory that a controlled, minor case would produce immunity without the risk of the full-blown disease. The technique had circulated for generations across West Africa, the Ottoman Empire, and Asia, and it reached Boston through the injustice of slavery. The Puritan minister Cotton Mather learned of it from Onesimus, a man he held in bondage, who described having undergone the procedure himself in Africa. Mather corroborated the account with other enslaved Africans in Boston and read reports out of Constantinople before becoming inoculation’s loudest champion.
Physician Zabdiel Boylston put the idea into practice, inoculating his own son and two enslaved members of his household first, then expanding the program despite fierce opposition. The city’s medical establishment largely revolted. Dr. William Douglass, one of the few Bostonians who actually held a medical degree, led the case against inoculation on grounds that ranged from the religious objection, that deliberately spreading disease usurped divine providence, to a reasonable-for-the-time scientific worry that the practice itself was seeding new outbreaks. The argument did not stay academic. Someone threw a lit grenade through Mather’s window that November, with a note attached reading, in essence, that he could inoculate himself with the bomb. It failed to detonate.
The case against inoculation was never purely religious or clinical; it was tangled up with its origin. Opposition writers repeatedly invoked its African and Ottoman source as grounds for distrust, treating its foreign, non-Christian lineage as evidence of danger apart from any medical argument. One Boston pamphleteer asked why residents should “cherish the cruel Blood of Africa or Asia” in their bodies, and a London critic writing a decade later dismissed inoculation as a “barbarous and dangerous Invention” imported from Turkey that had wrought “Havock and Slaughter” once it took hold. Because the technique reached Boston through Onesimus, the racial dimension of the debate was impossible to separate from the medical one — critics were rejecting a treatment in part because of who had brought it, not because of what it did.
What makes 1721 more than a historical curiosity is that Boylston and his allies did something close to a clinical study. They tallied outcomes among the inoculated against outcomes among those who caught smallpox naturally, and the inoculated group fared markedly better. That comparison helped slowly tip opinion in inoculation’s favor over the following decades. By the time George Washington ordered mandatory inoculation of the Continental Army in 1777, the practice — though still controversial — had become an accepted tool of public health.
The Gilded Age Leagues: Liberty, Quackery, and the Courts
Edward Jenner’s cowpox vaccine, introduced in 1796, eventually replaced variolation as the standard smallpox prevention. As vaccination spread across the Atlantic world through the nineteenth century, so did organized resistance. Britain passed an 1853 law making infant vaccination compulsory, and an 1867 act extended the mandate to age fourteen with real penalties attached for refusal. Britons who objected on religious, medical, or libertarian grounds organized the Anti-Vaccination League and, in 1867, the Anti-Compulsory Vaccination League, and within a few years it claimed over a hundred branches and roughly 10,000 members.
The British campaigner William Tebb carried that movement across the Atlantic. Following Tebb’s visit, Americans opposed to compulsory vaccination founded the Anti-Vaccination Society of America in 1879, and the New England Anti-Compulsory Vaccination League followed in 1882. These organizations drew on a mix of motives that will sound familiar to a modern reader: a libertarian objection to state intrusion into personal and parental decisions, religious conviction that disease and its prevention were matters for providence, and — more cynically — the financial interests of the era’s patent-medicine sellers and homeopaths, whose loosely regulated business model was directly threatened by a state-endorsed, evidence-based alternative.
The movement’s grievances were not entirely invented. In 1901, contaminated diphtheria antitoxin killed thirteen children in St. Louis, and contaminated smallpox vaccine killed several more in Camden, New Jersey, in the same year. Congress responded with the Biologics Control Act of 1902, the first federal law requiring licensure and safety standards for vaccine manufacturers — an early ancestor of the FDA’s modern oversight role. Those tragedies, however, did not settle the legal question of whether a state could force the issue. That came in 1905, when the Supreme Court decided Jacobson v. Massachusetts, upholding a Cambridge ordinance that fined residents who refused smallpox vaccination during an outbreak. The Court held that individual liberty was not absolute and could yield to a state’s power to protect public health — the first Supreme Court ruling on the subject, and one still cited today in disputes over compulsory vaccination and other public health mandates.
The ruling galvanized rather than pacified the opposition. Three years later, in 1908, opponents founded the Anti-Vaccination League of America in Philadelphia, built on the principle — in the League’s own words — that health was nature’s greatest safeguard against disease and that no state had the right to demand its impairment. It had the stated goal of abolishing what it called oppressive medical laws. Charles Higgins, one of the League’s most prolific pamphleteers, published tracts like his 1912 broadside “Open Your Eyes Wide!” arguing that vaccination was both dangerous and a violation of fundamental freedom. When Texas tried to require vaccination for public school attendance, the League’s arguments resurfaced in Zucht v. King, a 1922 case in which the Supreme Court again sided with the state.
Polio and The Vaccine Disasters of the 20th Century
By the mid-twentieth century, American vaccine skepticism had a new source of fuel, manufacturing failures serious enough to validate the movement’s oldest fear, that the shot itself might cause the disease. On April 12, 1955, officials announced that Jonas Salk’s inactivated polio vaccine, tested in a trial of 1.8 million children, was safe and effective, and the federal government licensed five manufacturers within days to begin mass production. One of them, Cutter Laboratories of Berkeley, California, shipped batches in which the virus-inactivation process had failed, leaving live, virulent polio virus in vaccine given to roughly 200,000 children across five states. An estimated 40,000 developed abortive polio, 200 were left with some degree of paralysis, and at least ten died. The program was suspended within weeks, federal oversight of vaccine manufacturing was overhauled, and vaccination resumed that fall under tighter controls.
The Cutter Incident became a formative episode in the history of American vaccine regulation and it had a lasting effect: a generation of parents who had watched the worst-case scenario for the trustworthiness of vaccines play out on the evening news, and that memory did not fade quickly.
Two decades later, a different kind of failure struck the flu vaccine. In early 1976, an Army recruit at Fort Dix, New Jersey, died of an influenza strain resembling the one responsible for the catastrophic 1918 pandemic. Fearing a repeat, the Ford administration pushed Congress to fund a crash national vaccination campaign, and nearly 43 million Americans were vaccinated within about ten weeks — an extraordinary logistical feat. The anticipated pandemic never arrived. Worse, as vaccinations proceeded, epidemiologists began detecting a modest but real increase in Guillain-Barré syndrome, a rare autoimmune paralytic condition, among recipients — roughly one additional case per 100,000 doses by later estimates. The program was suspended in December 1976, the CDC director was fired on live television, and the New York Times dubbed the whole affair a “fiasco,” a label that stuck for decades.
The Flu Shot’s Persistent Image Problem
Unlike smallpox or polio vaccination, the annual flu shot has never fully shaken a reputation for being optional, unpleasant, and only modestly effective in any given year. This is largely because the vaccine’s composition is re-engineered annually against strains predicted months in advance. That combination of a recurring injections, a variable and sometimes underwhelming efficacy rate, and the folk memory of 1976 has kept flu vaccination rates well below public health targets in most seasons, hovering in recent years around half of American adults, with substantial swings by age, region, and political affiliation. There is still the belief among some groups that the vaccine itself can cause flu even though flu vaccines do not contain live virus and cannot cause the disease.
COVID-19: An Old Argument at Unprecedented Speed
The COVID-19 pandemic compressed a century of vaccine controversy into about eighteen months. The mRNA vaccines developed by Pfizer-BioNTech and Moderna, along with a viral-vector vaccine from Johnson & Johnson, received emergency authorization by early 2021 after a development timeline that was, by historical standards, astonishingly fast. It was a point public health officials framed as a triumph of scientific investment and one that vaccine skeptics framed as a reason for caution. By September 2021, about 62 percent of Americans age twelve and older had received at least one dose, but demand had already begun slowing well before the country approached anything like universal coverage.
What followed diverged from earlier vaccine controversies in one important respect, hesitancy did not fade as more safety data accumulated, and in some respects it hardened. One national longitudinal study found that COVID-19 vaccine refusal actually rose from about 41 percent of adults in 2021 to nearly 45 percent in 2022. Even as overall vaccination coverage climbed, belief in the vaccine’s broader social benefit fell sharply, from roughly 48 percent to 25 percent. Parental hesitancy about vaccinating children against COVID-19 rose by nearly 16 percentage points in just nine months of 2021 and 2022, notably concentrated among white and rural parents, a pattern that cut against the demographic profile of vaccine resistance in earlier eras of American history. By the 2025–26 respiratory virus season, CDC surveillance found that only about 16 percent of American adults had received that season’s COVID-19 vaccine, with somewhat higher uptake — about 31 percent — among adults sixty-five and older, who face the greatest risk from the disease.
COVID-19 did not create vaccine skepticism, but it sharply politicized and enlarged the anti-vaccine movement by tying vaccination to partisan identity, distrust of government and public-health institutions, and debates over mandates, individual liberty, and pandemic restrictions. Political leaders, partisan media, and online networks often framed vaccination less as a medical decision grounded in evidence than as a symbol of cultural allegiance or resistance to perceived government overreach. Anti-vaccine activists used that environment to spread misinformation and reach audiences far beyond earlier disputes over childhood immunizations. The result was a more organized “health freedom” politics in which skepticism about COVID-19 vaccines could spill over into opposition to other routine vaccines, making public health a continuing front in America’s broader political polarization.
The pandemic-era pattern echoes several of its historical predecessors at once: distrust of a fast-moving federal program (echoing 1976), suspicion of a technology many found unfamiliar and difficult to evaluate (echoing the original inoculation debates of 1721), and a fusion of libertarian and religious objection to government mandates (echoing the Anti-Vaccination League of America a century earlier).
A Recurring American Argument
Over the last 50 years, advocacy groups have questioned the growing number of childhood vaccines and raised concerns about vaccine ingredients, scheduling, and possible long-term effects. The movement gained momentum after publication in 1998 of a now-retracted paper by Andrew Wakefield that falsely suggested a link between the measles-mumps-rubella (MMR) vaccine and autism. Numerous large studies subsequently found no evidence supporting such a connection, and investigations revealed ethical violations and scientific misconduct in Wakefield’s work, but the damage was done and the foundation was laid for the modern anti vaccination movement.
Read across three centuries, American vaccine resistance is not one continuous movement so much as the same underlying argument recurring in new costumes. It is a tension between collective protection and individual or parental autonomy, sharpened at each turn by episodes — some tragic and real, like Cutter and the 1976 swine flu campaign, some largely fabricated, like William Tebb’s invented nineteenth-century casualty statistics — that gave skeptics evidence, or the appearance of it, to point to. The debate has never been resolved so much as relitigated, generation after generation, against whatever the era’s most feared disease happens to be.
Disclaimer: The author writes independently. The views expressed here are his own and are not made on behalf of, and should not be attributed to, any hospital, university, or other institution with which he is affiliated. This article is a work of historical journalism, not medical advice.
Image generated by the author using ChatGPT.
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Our Shared Story Can Still Bring Us Together
By John Turley
On August 18, 2026
In Commentary
I’ve been a member of the Sons of the American Revolution for quite some time now. At the beginning of April, I started looking around for a Memorial Day event that we could join. I had assumed that my hometown of Charleston WV, being the state capital, would surely have an event since it is the 250th anniversary of the Declaration of Independence. I was surprised to find that none was planned.
I believed that it was especially important that a Memorial Day service be held here because West Virginia has, since World War II, one of the highest per capita rates of military service and combat casualties in the country. So, another SAR member and I got together, and we planned our own event and arranged for it to be held on the state capitol grounds. At the end of our service, I looked out at the group that was gathered: there was no right or left, there was no red or blue, there was no conservative or liberal. There were only proud Americans who had come together to honor our country, its veterans and its history.
Americans disagree about almost everything these days. Politics, religion, education, history, and even the meaning of patriotism have all become subjects of bitter debate. Too often, we define ourselves more by the groups we oppose than by the country we share.
Yet there are still opportunities to remember that before we were Republicans or Democrats, conservatives or progressives, we were Americans. The ongoing 250th Anniversary of the Revolutionary Era offers one of those rare opportunities to express what we share, not how we differ.
The semiquincentennial should be far more than fireworks, parades, and historical reenactments. It should be an invitation to rediscover the remarkable story we all inherited. The American Revolution was not perfect. The nation it created was imperfect from the beginning, carrying the stain of slavery, denying women equal rights, and often failing to live up to its own ideals. Those shortcomings do not erase the extraordinary achievement of creating a republic founded on the revolutionary belief that legitimate government derives its authority from the consent of the governed.
The founders left us more than a nation. They left us a challenge. Every generation has been asked to move the country a little closer to the principles expressed in the Declaration of Independence—that all people are created equal and possess inherent rights that no government should take away. Those words have inspired abolitionists, suffragists, civil rights leaders, immigrants seeking freedom, and millions of ordinary citizens who believed America could become better than it was.
That is a heritage worth celebrating together.
Organizations devoted to civic life have an important role to play in that celebration. Groups such as the Sons of the American Revolution, the Daughters of the American Revolution, the American Legion, Rotary clubs, Civitan clubs, veterans’ organizations, scouting groups, historical societies, libraries, museums, churches, and countless other local groups have spent decades preserving history, encouraging volunteerism, supporting education, and strengthening their communities. While each has its own mission and traditions, they all remind us that citizenship is more than voting every few years. It is an ongoing commitment to serving neighbors and improving the places where we live.
These organizations also offer something increasingly rare in modern America: opportunities for people with different political views to work side by side on practical goals. A community service project, a scholarship program, a veterans’ memorial, a food drive, or a history program rarely asks participants how they voted. It asks only if they are willing to help.
That is a lesson our country desperately needs. Social media and cable television often reward outrage. Algorithms profit by convincing us that our fellow Americans are enemies rather than neighbors. It becomes easy to believe that our differences outweigh everything we have in common.
History tells a different story. Americans have survived fierce political battles before. We have argued over the Constitution, endured civil war, struggled through economic depression and assassinations, fought world wars, and confronted profound disagreements about civil rights and social change. Our history has never been one of perfect unity. Instead, it has been a continuing effort to find common purpose despite deep disagreements.
The Revolution itself offers an example. The thirteen colonies differed enormously in religion, economy, geography, and culture. New England merchants, Virginia planters, Pennsylvania farmers, and South Carolina traders often had conflicting interests. Yet they discovered that some principles were more important than their differences. Their unity was never complete, but it was sufficient to build a nation. We face no less important a challenge today.
The 250th anniversary should encourage every community to host public readings of the Declaration of Independence, historical lectures, concerts, service projects, naturalization ceremonies, veterans’ recognitions, student essay contests, and volunteer events that welcome everyone. These occasions should not become platforms for partisan speeches. They should remind us that our history belongs to all Americans.
Celebrating our shared heritage does not require us to ignore the darker chapters of our past. Mature patriotism is honest enough to acknowledge failures while remaining grateful for the ideals that allowed those failures to be challenged and corrected. A confident nation can tell its whole story without either whitewashing its mistakes or denying its accomplishments.
Perhaps that is the greatest gift the 250th anniversary can offer is reminding us that America has always been a work in progress. Each generation inherits both the nation’s achievements and its unfinished work. If we can gather to honor the courage, sacrifice, and aspirations of those who came before us, perhaps we can rediscover something that has become increasingly scarce — the ability to see one another first as fellow citizens.
Our common heritage cannot solve every political disagreement. It will not erase ideological differences or end heated debates about the country’s future. Nor should it. Democracy depends upon vigorous debate. But it also depends upon something deeper — a shared commitment to our republic and our active participation as citizens. We need to become informed participants in our society and we need to vote and encourage others to vote.
As we celebrate America’s 250th birthday, the greatest act of patriotism is not winning another political argument. It is remembering that despite our many differences, we remain participants in the same remarkable American experiment. If civic organizations, veterans’ groups, historical societies, schools, churches, and local communities can help us rediscover that simple truth, they will have performed one of the greatest public services imaginable.
The founders gave us a republic, and they challenged each generation to preserve it and to improve it. Two hundred and fifty years later, that responsibility belongs to all of us. We must not fail.
Image generated br author using ChatGPT.