
Today I’m going to talk about something that may sound unbelievable and maybe even a little gross—fecal transplant. Yes, it’s exactly what it sounds like. Getting a transplant of someone else’s poop.
The human gut contains trillions of microorganisms—bacteria, viruses, fungi—living in a complex ecosystem that influences everything from digestion to immune function. This is called the microbiome. When this ecosystem gets disrupted, the consequences can range from uncomfortable to life-threatening. Enter one of medicine’s most counterintuitive treatments: fecal microbiota transplantation, or FMT, where stool from a healthy donor is transferred to a patient to restore a healthy community of gut microbes.
What Is FMT
The basic idea is simple: if someone’s microbiome has been badly disrupted (most commonly by repeated antibiotic exposure), replacing it with a balanced microbial ecosystem can help the gut recover. At its core, FMT is taking fecal matter from a healthy donor and introducing it into a patient’s gastrointestinal tract. But it’s not the solid waste itself that matters; it’s the billions of beneficial bacteria and other microorganisms living in that material. Think of it as a probiotic treatment on steroids, delivering an entire functioning ecosystem rather than just a few select bacterial strains.
The gut microbiome plays crucial roles in digestion, vitamin production, immune system regulation, and even protection against harmful pathogens. When antibiotics, illness, or other factors devastate this ecosystem, dangerous bacteria like Clostridioides difficile (C. diff) can take over, causing severe diarrhea, inflammation, and potentially fatal infections.
The Clinical Track Record
While it may sound like “weird science”, FMT has been around for centuries. It was used in ancient Chinese medicine in a formulation called “yellow soup“ to treat food poisoning and intractable diarrhea. It was used as early as the 16th century in Europe to treat sick farm animals, particularly sheep and cattle.
FMT’s most dramatic success story involves C. diff infections, particularly the recurrent cases that don’t respond to antibiotics. Multiple randomized controlled trials have shown FMT to be remarkably effective—with cure rates often exceeding 80-90% for recurrent C. diff infections, compared to roughly 25-30% for continued antibiotic therapy. A landmark 2013 study reported in the New England Journal of Medicine was stopped early because FMT was so dramatically superior to standard treatment that continuing to withhold it from the control group seemed unethical.
Beyond C. diff, researchers are investigating FMT for inflammatory bowel diseases like ulcerative colitis and Crohn’s disease, with mixed but occasionally promising results. Some studies have shown potential for ulcerative colitis, with remission rates around 24-27%. The research into Crohn’s disease, irritable bowel syndrome, metabolic disorders, and even neurological conditions is ongoing but less conclusive. The FDA currently considers FMT an investigational treatment for most conditions except recurrent C. diff, where it’s become a recognized therapeutic option.
How It Works
The actual process of FMT can use several routes. The most common approaches involve colonoscopy, where the donated material is delivered directly to the colon, or through nasogastric or nasoduodenal tubes that thread through the nose down to the small intestine. More recently, oral capsules containing frozen, encapsulated donor stool have become available, offering a less invasive alternative that patients often prefer.
Before the transplant, the donated stool is carefully processed. It’s typically mixed with a saline solution and filtered to remove large particles while preserving the microbial communities. The resulting liquid suspension is what gets delivered to the patient. For frozen preparations, this material is mixed with a cryoprotectant, frozen at extremely cold temperatures, and can be stored for months before use.
The preparation isn’t just about the donor material—patients often undergo their own preparation. Many protocols include antibiotics to reduce the overgrowth of harmful bacteria before the transplant, followed by bowel cleansing similar to what you’d do before a colonoscopy. The idea is to create a relatively clean slate where the new microbial ecosystem can establish itself.
Sources of Donor Material
This brings us to one of the most critical aspects: donor selection and screening. Not just anyone can donate stool for medical use. The screening process is extensive and rigorous, rivaling or exceeding the scrutiny applied to blood donation.
Donors undergo detailed health questionnaires covering everything from recent travel and antibiotic use to gastrointestinal symptoms and risk factors for infectious diseases. They provide blood and stool samples that are tested for a long list of potential pathogens: C. diff, Helicobacter pylori, parasites, hepatitis A, B, and C, HIV, syphilis, and various other bacteria and viruses. The FDA issued guidance requiring additional testing for multi-drug resistant organisms after several patients contracted serious infections from FMT.
Donors generally fall into two categories: directed donors and universal donors. Directed donors are typically family members or friends who undergo screening and provide stool specifically for one patient. Universal donors go through the same rigorous screening but provide samples that can be used for multiple patients. These universal donors often work with stool banks—specialized facilities that collect, process, screen, and distribute donor material to healthcare providers.
The largest stool bank in the United States, OpenBiome, was founded in 2012 and has processed material from thousands of donors for tens of thousands of treatments. They report that only about 2-3% of volunteer donors successfully make it through the screening process, highlighting just how selective the criteria are. These banks have made FMT more widely available, eliminating the need for individual healthcare facilities to find and screen their own donors.
The Balance of Promise and Caution
While FMT represents a genuine breakthrough for recurrent C. diff infections, the medical community remains appropriately cautious about expanding its use. The FDA regulates FMT and has expressed concerns about potential risks, particularly after cases where patients developed serious infections from inadequately screened donors. There questions about the long-term effects of introducing another person’s microbiome, and there are theoretical concerns about transmitting conditions or predispositions we don’t fully understand.
The research into FMT for conditions beyond C. diff continues, but many trials have shown modest or inconsistent results. The microbiome’s role in health and disease is incredibly complex, and what works dramatically for one condition may not translate to others. Still, the fundamental insight—that our gut microbiome profoundly influences our health and that we can therapeutically manipulate it—has opened potential new avenues in medicine.
Sources
1. van Nood, E., et al. (2013). “Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile.” New England Journal of Medicine, 368(5), 407-415. https://www.nejm.org/doi/full/10.1056/NEJMoa1205037
2. U.S. Food and Drug Administration. “Fecal Microbiota for Transplantation: Safety Information.” https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/fecal-microbiota-transplantation-safety-information
3. Cammarota, G., et al. (2017). “European consensus conference on faecal microbiota transplantation in clinical practice.” Gut, 66(4), 569-580. https://gut.bmj.com/content/66/4/569
4. Moayyedi, P., et al. (2015). “Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial.” Gastroenterology, 149(1), 102-109. https://www.gastrojournal.org/article/S0016-5085(15)00381-5/fulltext
5. Kelly, C.R., et al. (2016). “Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook.” Gastroenterology, 150(1), 276-290. https://www.gastrojournal.org/article/S0016-5085(15)01626-7/fulltext
6. OpenBiome. “Our Process: Screening.” https://www.openbiome.org/safety
7. Quraishi, M.N., et al. (2017). “Systematic review with meta-analysis: the efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory Clostridium difficile infection.” Alimentary Pharmacology & Therapeutics, 46(5), 479-493. https://onlinelibrary.wiley.com/doi/full/10.1111/apt.14201
Illustration generated by author using Midjourney












Truth at a Crossroads: How Trust, Identity, and Information Shape What We Believe
By John Turley
On February 2, 2026
In Commentary
When Oxford Dictionaries declared “post-truth” its word of the year in 2016, it crystallized something many people had been feeling: that we’d entered a strange new era where objective facts seemed less influential in shaping public opinion than appeals to emotion and personal belief. The term exploded in usage that year, becoming shorthand for a troubling shift in how we process information. But have we really entered uncharted territory, or is this just the latest chapter in a very old story?
The short answer is: it’s complicated. The phenomenon itself isn’t new, but the scale and speed at which misinformation spreads certainly is. We are in a new world where the boundary between truth and untruth is blurred, institutions that once arbitrated facts are losing authority, and politics are running on “truthiness” and spectacle more than evidence.
The Psychology of Believing What We Want to Believe
To understand why people increasingly seem to choose sources over facts, we need to dive into how our minds actually work. People now seem to routinely sort themselves into information camps, each with its own “truth,” trusted voices, and shared worldview. But why is this and why does it seem to be getting worse?
Psychologists have spent decades studying something called confirmation bias—essentially, the tendency to seek out information that supports our existing beliefs while avoiding or dismissing information that contradicts them. This isn’t just about being stubborn. Research shows we actively sample more information from sources that align with what we already believe, and the higher our confidence in our initial beliefs, the more biased our information gathering becomes.
But there’s something even more powerful at play called motivated reasoning. While confirmation bias is about seeking information that confirms our beliefs, motivated reasoning is about protecting ideological beliefs by selectively crediting or discrediting facts to fit our identity-defining group’s position. In other words, we don’t just want to be right—we want to belong.
This matters because humans are fundamentally tribal creatures. When we form attachments to groups like political parties or ideological movements, we develop strong motivations to advance the group’s relative status and experience emotions like pride, shame, and anger on behalf of the group. Information processing becomes less about truth-seeking and more about identity protection.
Why Source Trumps Fact
So why do people trust a source they identify with over objective facts that contradict their worldview? Research points to several interconnected reasons.
First, there’s the practical matter of cognitive shortcuts. We’re bombarded with information daily, and people judge the reliability of evidence by using mental shortcuts called heuristics, such as how readily a particular idea comes to mind. If someone we trust says something, that’s an easier mental pathway than laboriously fact-checking every claim. This reliance becomes problematic when “trusted” means ideologically comfortable rather than factually reliable.
Analysts of the post‑truth phenomenon also highlight declining trust in traditional “truth tellers” such as mainstream media, scientific institutions, and government agencies. As these institutions lose authority, counter‑elites or influencers can present alternative narratives that followers treat as at least as plausible as established facts
Second, and more importantly, is the issue of identity. When individuals engage in identity-protective thinking, their processing of information more likely guides them to positions that are congruent with their membership in ideologically or culturally defined groups than to ones that reflect the best available scientific evidence. Being wrong about a fact might sting for a moment, but being cast out of your social group could have real consequences for your emotional support, social standing, and sense of self.
Third, there’s a feedback loop at work. In social media, confirmation bias is amplified by filter bubbles and algorithmic editing, which display to individuals only information they’re likely to agree with while excluding opposing views. The more we’re exposed only to sources that confirm our beliefs, the more alien and untrustworthy contradictory information appears.
Interestingly, being smarter doesn’t necessarily protect you from these biases. Some research suggests that people who are adept at using effortful, analytical modes of information processing may actually be even better at fitting their beliefs to their group identities, using their intelligence to construct more sophisticated justifications for what they already want to believe.
The Historical Echo Chamber
Despite the way it feels, this isn’t the first time truth has had competition. History is full of eras when myth, rumor, propaganda, and identity overshadowed facts.
During The Reformation of the1500s, misinformation was spread on both sides of the catholic-protestant divide. Pamphlets—many of them highly distorted or outright fabricated—spread rapidly thanks to the printing press. Propaganda became a political weapon. Ordinary people suddenly had access to arguments they weren’t equipped to verify. People were ostracized and some even executed based on little more than rumors or lies. We might have hoped for better from religious leaders.
The French Revolution (1780s–1790s) was awash in claims and counterclaims, many of them—if not most—had little basis in fact.Competing newspapers told wildly different stories about the same events. Rumors fueled paranoia, purges, and violence. Truth became secondary to whichever faction controlled the narrative.
Following the Civil War and Reconstruction, the “Lost Cause” narrative became a powerful example of source-driven myth making. Despite historical evidence, generations accepted a version of events shaped by postwar Southern elites, not by facts. Echoes of it still reverberate today, driving much of the opposition to the civil rights movement.
Fast forward to the 1890s, and we see something remarkably familiar. Yellow journalism, characterized by sensationalism and manipulated facts, emerged from the circulation war between Joseph Pulitzer’s New York World and William Randolph Hearst’s New York Journal. These papers used exaggerated headlines, unverified claims, faked interviews, misleading headlines, and pseudoscience to boost sales.
As early as 1898, a publication for the newspaper industry wrote that “the public is becoming heartily sick of fake news and fake extras”—sound familiar?
During the 20th-century propaganda states, typified by both fascist and communist regimes perfected source-based truth. The leader or the party defined reality, and disagreement was literally dangerous. In these systems, truth wasn’t debated—it was assigned.
What Makes Now Different?
While the psychological mechanisms and even the tactics aren’t new, several factors make our current moment distinct. The speed and scale of information spread is unprecedented. A false claim can circle the globe in hours. Studies show that people are bombarded by fake information online, leading the distinction between facts and fiction to become increasingly blurred as blogs, social media, and citizen journalism are awarded similar or greater credibility than other information sources.
We’re also experiencing a fragmentation of trusted authorities. Where once a handful of major newspapers and broadcast networks served as gatekeepers, now the fragmentation of centralized mass media gatekeepers has fundamentally altered information seeking, including ways of knowing, shared authorities, and trust in institutions.
So Are We in a Post-Truth Era?
Yes and no. The term “post-truth” captures something real about our current moment—the scale, speed, and sophistication of misinformation is unprecedented. But calling it “post-truth” suggests we’ve crossed some bright line into entirely new territory. I’d argue we’re not quite there—but we are navigating a world where truth is sometimes lost in the collision of ancient human tendencies and modern technology
The data clearly show that confirmation bias, motivated reasoning, and identity-protective cognition are real and powerful forces. Historical evidence demonstrates that propaganda, misinformation, and the choice of tribal loyalty over objective fact have been with us for millennia. What’s changed is our information ecosystem driven by the technology that allows false information to spread faster than ever, and the by the fragmentation of shared sources of authority that once helped create common ground.
Perhaps a better framing would be that we’re in an era of “turbo-charged tribal epistemology”—where our very human tendency to trust our tribe’s narrative over contradicting evidence has been supercharged by algorithms that feed us what we want to hear and isolate us from alternative perspectives. (I wish I could take credit for the term turbo-charged tribal epistemology. I really like it, but I read it somewhere, I just can’t remember where.)
The question isn’t really whether we’re in a post-truth society. The question is whether we can develop the individual and collective skills to navigate an information environment that exploits every cognitive bias we have. The environment has changed, but the task remains the same: finding ways to establish shared facts despite our deep-seated tendency to believe what we want to believe.
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