
Chronic kidney disease (CKD) affects approximately 37 million Americans, with adults over 65 representing the fastest-growing group diagnosed. Often called a “silent disease,” CKD can progress for years without noticeable symptoms, making awareness and early detection crucial for preserving kidney function and overall health.
What Is Chronic Kidney Disease?
Chronic kidney disease occurs when the kidneys gradually lose their ability to filter waste products and excess fluid from the blood. Unlike acute kidney injury, which happens suddenly and can be quickly corrected, CKD develops slowly over months or years and is generally not reversable. The kidneys perform several vital functions beyond filtration, including regulating blood pressure, supporting production of red blood cells, and maintaining the body’s chemical balance. When kidney function declines, these processes become compromised, leading to serious health complications if left untreated.
The disease progresses through five stages, from mild kidney damage with normal filtration to complete kidney failure requiring dialysis or transplantation. Understanding this progression helps patients and healthcare providers make informed decisions about treatment and lifestyle modifications.
Risk Factors: Who’s Most Vulnerable?
Several factors significantly increase the risk of developing CKD, with diabetes and high blood pressure being the leading causes and accounting for nearly two-thirds of all cases.
Type 2 diabetes, which affects over 11% of the U.S. population, damages the small blood vessels in the kidneys impairing their filtering capacity. Kidneys also play a role in glucose management by clearing insulin from the body. As kidney function declines, insulin stays in the system longer reducing circulating glucose levels.
Hypertension creates a destructive cycle of progressive kidney disease. It damages kidney blood vessels, reducing their effectiveness, causing the kidneys to struggle to regulate blood pressure, creating further blood pressure elevation, leading to greater damage. This relationship makes blood pressure control essential for both prevention and treatment.
Age itself is a significant risk factor. After age 40, kidney function naturally declines by approximately 1% per year. However, this normal aging process can accelerate in the presence of other risk factors. Family history also plays a role, particularly for conditions like polycystic kidney disease and certain genetic disorders affecting kidney function.
Other risk factors include cardiovascular disease, obesity, smoking, and prolonged use of certain medications, particularly nonsteroidal anti-inflammatory drugs (NSAID—aspirin, ibuprofen, etc) and some prescription medications. African Americans, Hispanic Americans, and Native Americans face higher risks due to genetic predisposition and higher rates of diabetes and hypertension. As with all chronic medical conditions, the detrimental effect of smoking cannot be overstated.
Recognizing the Signs: Symptoms of CKD
The insidious nature of CKD means symptoms often don’t appear until after significant kidney damage has occurred. Early-stage CKD may produce no symptoms at all, which is why routine screening for at-risk individuals is so important.
As the disease progresses, symptoms may include persistent fatigue and weakness which are often dismissed as normal aging. Patients may have trouble concentrating, sleep problems, decreased appetite and persistent nausea. Swelling in the feet, ankles, or around the eyes can indicate fluid retention due to impaired kidney function.
Changes in urination patterns may occur, including increased frequency, especially at night, or decreased urine output. The urine may appear foamy, indicating protein spillage, or may be darker in color. Some patients experience persistent itching due to waste product buildup in the blood.
More advanced CKD can cause severe nausea, vomiting, muscle cramps, and shortness of breath. High blood pressure may develop or worsen, and patients might experience chest pain or irregular heartbeats. These symptoms warrant immediate medical attention.
Diagnostic Testing: Identifying CKD
Early detection relies on simple, routine blood and urine tests that can identify kidney problems before symptoms appear. Your doctor will order blood tests and urine tests, and possibly imaging tests such as ultrasounds to evaluate your risk for kidney disease. Frequently these tests will check for many other things such as anemia, high cholesterol or diabetes. All of these can contribute to chronic kidney disease.
Treatment Approaches: Managing CKD
While CKD cannot be cured, proper treatment can significantly slow progression and manage complications. The primary goals include treating underlying causes, slowing decline of kidney function, and managing associated health problems.
Blood pressure control is paramount, with target levels typically below 130/80 mmHg for most CKD patients. ACE inhibitors and ARBs (angiotensin receptor blockers) are preferred medications as they provide additional kidney protection beyond blood pressure reduction.
Diabetes management requires maintaining hemoglobin A1c levels below 7% for most patients. Newer medications like SGLT2 inhibitors show promise in protecting kidney function while controlling blood sugar.
Dietary modifications play a crucial role in CKD management. Reducing sodium intake helps control blood pressure and fluid retention. Protein restriction may be recommended in advanced stages to reduce kidney workload, though this requires careful monitoring to prevent malnutrition.
Managing complications becomes increasingly important as CKD progresses. This includes treating anemia with iron supplements or erythropoiesis-stimulating agents, managing bone and mineral disorders with vitamin D supplements and phosphate binders, and addressing cardiovascular risk factors.
For end-stage kidney disease, renal replacement therapy through dialysis or kidney transplantation becomes necessary. Early planning for these treatments improves outcomes and quality of life.
Prevention Strategies: Protecting Your Kidneys
Prevention remains the most effective approach to CKD. Maintaining healthy blood pressure through regular exercise, weight management, sodium reduction, and medication compliance are the foundations of kidney protection.
Diabetes prevention and management through lifestyle modifications and appropriate medical care significantly reduces CKD risk. Regular monitoring of blood sugar, blood pressure, and kidney function allows for early intervention when problems arise.
Avoiding nephrotoxic substances, including excessive NSAID use, staying hydrated, and not smoking all contribute to kidney health. Regular medical check-ups enable early detection and treatment of conditions that could lead to CKD.
Understanding chronic kidney disease empowers older adults to take proactive steps in prevention and to look for appropriate care when needed. With proper management, early detection, and comprehensive care, many people with CKD can maintain a good quality of life and slow disease progression.










Anti-Vax or Disease Supporter
By John Turley
On June 12, 2025
In Commentary, Medicine, Politics
Between June 9 and 11, 2025, HHS Secretary Robert F. Kennedy Jr. dismissed all 17 members of the CDC’s Advisory Committee on Immunization Practices—a body that has guided U.S. vaccine policy for about 60 years. He followed this by appointing eight new members, the minimum under the charter, including several known vaccine deniers.
In light of this, I have decided to repost an article I wrote over a year ago. (With new artwork.)
“There are two ways to be fooled. One is to believe what is not true; the other is to refuse to believe what is true.”
– Søren Kierkegaard
Saturday morning, I was reading in the newspaper about the resurgence of measles in West Virginia. I find it appalling that this disease should be returning, given that we have safe and effective vaccinations. What is next, polio, smallpox, or even plague? It is only through the unexpected veto by our [former] governor that the ill-advised bill passed by our legislature to make all vaccinations optional with a little more than a request by the parents, did not become law. [The current governor has issued an executive rendering vaccinations virtually optional for school children.]
Some people may wonder why vaccinations are important. There are two principal reasons to ensure that a large portion of the population is vaccinated against communicable diseases. The first is that it reduces the individual vulnerability to disease. The person who is vaccinated is protected. But there is also a second, sometimes not well-understood, reason. That is herd immunity.
Communicable diseases require a large susceptible population to spread. When a significant portion of the population has been vaccinated the disease does not have the core of potential victims to allow spreading. This means that the vaccinated are protecting the non-vaccinated. However, it does require a large portion of the population to be vaccinated. The idea is that herd immunity will protect those who are unable to be vaccinated either due to age, allergies, or other medical conditions that would prohibit vaccination. It is never going to protect a large proportion of the population who just choose not to be vaccinated. For example, about 90-95% of the population needs to be vaccinated against measles to provide herd immunity.
So why do people who otherwise can be vaccinated choose not to be?
There are, of course, those who have true religious objections to vaccination. There are others who object to vaccination on the basis of personal autonomy. They believe their right to refuse vaccination outweighs any consideration of the health concerns of the frail members of our community.
There are many who mistrust the medical system. There were some cases in the past where unethical studies were conducted on unsuspecting populations. Given the rigorous oversight of medical research now, this no longer happens. Information about research into vaccinations and their safety and efficacy can be found on websites for the Centers for Disease Control and Prevention and the World Health Organization among others. (Website references are provided at the end of this post.)
What concerns me most are those who refuse to believe reputable medical authorities, government agencies, and mainline news services. They prefer to get their information from anonymous websites or from conspiracy theory websites that still give credence to the now-discredited 1999 study linking the MMR vaccine to autism. They completely ignore the fact that 10 of the 11 reported co-authors disavowed any part in the conclusions of the study. They also ignore the fact that the principal author was found guilty of fraud for personal gain as he was employed by the manufacturer of rival drugs. They also ignore the fact that he lost his medical license over his falsifications in this study. Yet, he is still cited in anti-vaccine literature as an expert source.
Equally disturbing is the fact that vaccine resistance has become a part of political identification. Certain reactionary political groups have, for some unfathomable reason, decided that refusing vaccination is a badge of their political allegiance. They seem to care more about maintaining their political purity than they care about science, public health, or even the welfare of their family and friends. Politicizing public health is dangerous for all of us. I’m not sure how we overcome this. It is easy to find the truth and verify it through fact-based studies, yet people refuse to do it. [See my post Choosing Not To Know.]
I encourage everyone to work hard to ensure that our political leaders do not remove vaccination mandates for school children. For those of us of my age, we already have immunity through vaccination or prior exposure to the disease. It is our grandchildren and their children and their children’s children who will suffer through the return of these deadly diseases.
Rather than “vaccine deniers,” they should be referred to as “disease supporters.”
SOURCES:
World Health Organization: https://www.who.int/health-topics/vaccines-and-immunization#tab=tab_1
CDC: https://www.cdc.gov/vaccines/index.html https://www.cdc.gov/vaccines/hcp/vis/index.html
WV DHHR: https://oeps.wv.gov/immunizations/Pages/default.aspx
Immunise.org: https://www.vaccineinformation.org/